Since a large number of ANO1-interacting proteins were discovered using proteomics techniques in ANO1 over-expressing HEKT293 cells and the HNSCC cell line Tel1 [20,41], it is plausible that these putative ANO1-interacting proteins may also be involved in the regulatory mechanisms of ANO1-mediated tumorigenesis in ANO1-enriched cancer cells, including glioblastoma cells. Here, ANO1 is linked to head and neck squamous cell carcinoma.