In summary, CAV-1 mainly plays a role in activation or suppression in the following signal pathways in the context of virus infections: (1) Ras signaling pathway; (2) VEGF-mediated signaling pathways; (3) iNOS-mediated responses; (4) p53′s function; (5) IFN signaling pathways; (6) RhoA GTPase signaling pathways (summarized in Table 2). Here, CAV1 is linked to viral infectious disease.