Hemoglobin (Hb) also decreases the expression of nephrin and synaptopodin, two multifunctional proteins that maintain the structural integrity of the slit diaphragm and glomerular filtration function [46], partially explaining the PNH urinary manifestation in the course of Hb oxidative injury. The gene discussed is GSTM1; the disease is paroxysmal nocturnal hemoglobinuria.