Although its efficacy has been demonstrated in clinical trials [4,5], the number of patients benefited by this procedure is unfortunately low, around 5% of all stroke patients [1,6], a fact ascribed to the narrow time window for t-PA administration (3–4.5 h after stroke) and because delayed thrombolytic therapy and blood reperfusion have been associated with a high risk of hemorrhagic transformation and oxidative stress, thus causing additional damage. The gene discussed is PLAT; the disease is Stroke.