BACE1 and early-onset autosomal dominant Alzheimer disease: When the β-amyloid cleaving enzyme (BACE), which plays an active role in Alzheimer’s Disease, is incorporated to those polymer-cushioned lipid bilayers with varying physicochemical properties, the cushioning of supported lipid membrane leads to an increase in the incorporation and enzymatic activity of the reconstituted BACE with a direct correlation between lipid mobility and BACE activity [330].