MAPT and Alzheimer disease: In another study of 87 Drosophila genes, each with a human homolog identified in GWAS as an AD–associated genomic locus, nine were found to strongly affect the toxicity of Tau: CD2AP (cindr), SNRPN (SmB), PTPRD (Lar), XYLT1 (oxt), FERMT2 (Fit 1, Fit 2), CELF1 (aret), MAST4 (CG6498), ITGAM (scb), and ITGA9 (scb) [39].