Donepezil might also ameliorate oxaliplatin-induced peripheral neuropathy [136] and confer protection against induced seizures in a mouse model (Scn1a+/-) of Dravet syndrome, an encephalopathy caused by de novo loss-of-function mutations in the SCN1A gene [137]. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.