CYP3A5 and Anxiety: About 70% of drugs currently used for the treatment of anxiety, panic attacks, sleep disorders, agitation, and behavioral anomalies are major substrates of CYP3A4, followed by CYP2C19 (41%); CYP3A5 (38%); CYP2D6 (36%); CYP2C9 (30%); CYP1A2 (27%); CYP2B6 (19%); UGT1A4 (14%); UGT2B15 (11%); and UGT1A1, UGT1A3, UGT1A6, UGT1A10, and UGT2B7 (8%); only 10% are inhibitors of CYP3A4 and CYP2C9; 8% are inducers of CYP3A4, and about 5% are inducers of CYP1A2, CYP2A6, CYP7A1, and ABCC2.