The expression of PARK7 significantly increases in both primary tumors of esophageal squamous cell carcinoma (ESCC) and lymph node metastases, compared to that of the non-neoplastic esophageal epithelium, and there are no differences in the expression of PARK7 between primary tumors of ESCC and lymph node metastases. Here, PARK7 is linked to esophageal squamous cell carcinoma.