In breast cancer, the increased secretion of PARK7 and low expression of retained PARK7 have been more frequently detected in invasive ductal carcinomas than in ductal carcinomas in situ, and this expression pattern is found to be significantly associated with the high histological grade, large tumor size, and reduced survival of patients with breast cancer [70,71,72]. The gene discussed is PARK7; the disease is ductal breast carcinoma in situ.