Xanthoangelol, a principal chalcone constituent isolated from the stem exudates of Angelica keiskei, induces the apoptosis of neuroblastoma cells by inducing the generation of ROS and reduction of proteins related to oxidative stress, including PARK7, peroxiredoxin 6, triosephosphate isomerase 1, glyceraldehyde-3-phosphate dehydrogenase, and phosphoglycerate mutase 1, which consequently increases oxidative stress and induces apoptosis. The gene discussed is PARK7; the disease is neuroblastoma.