Treatment with the DNA-damaging agent, MMC, induces TP53 in HCT116 TP53+/+ cells, and the upregulation of TP53 induces the phosphorylation of PARK7 by MAPK8 or via a downstream target of a MAPK8-mediated, transcription-independent event, indicating that the phosphorylation of PARK7 mediated by TP53 may inhibit its function, and subsequently facilitate the apoptosis of CRC cells [119]. This evidence concerns the gene MAPK8 and colorectal carcinoma.