PARK7 is upregulated in bortezomib-resistant MM cells by upregulating the expression of c-Myc, Hypoxia Inducible Factor 1 Subunit α (HIF1A), Vascular endothelial growth factor (VEGF), and Glucose transporter 1 (GLUT1) [50]. Here, PARK7 is linked to Miyoshi myopathy.