NOS3 and neoplasm: We first used the calibrated model to simulate the eNOS signaling dynamics stimulated with various VEGF concentrations taken from observed ranges, including concentrations at the lower bound of the range found in healthy tissue (0.0003 nM) [95,96], the lower and upper bounds of the range in tumor tissue (0.008 nM and 0.389 nM, respectively) ([97], and as compiled in [65]); and a concentration of exogenous VEGF concentration frequently used in experimental studies (1.1 nM; 30 ng/mL).