Specific TILs such as CD8+ cytotoxic T lymphocytes, T helper 1 cells, M1 macrophages, natural killer (NK) cells, and T-follicular helper (Tfh) cells have been reported as exhibiting anti-tumor activities, whereas T-regulatory (Treg) cells and M2 macrophages are known for their immune-inhibitory and thus pro-tumor activities [7]. Here, CD8A is linked to neoplasm.