EZH2 and Ewing sarcoma: EZH2 in Ewing sarcoma is a downstream target of the product of the disease-defining translocation, Ewing sarcoma breakpoint region 1-Friend leukemia integration 1 transcription factor (EWSR1-FLI1) [65] and an important contributor to self-renewal, tumorigenicity and phenotypic heterogeneity in this cancer [65,66,67].