It has been shown that high ABCB5 expression was significantly related to tumor formation, metastasis and recurrence in OSCC and ABCB5 was co-labeled with CD44 (oral CSC marker) [8], suggesting ABCB5 was associated with oral CSCs and multistep carcinogenesis of OSCC [8,26]. The gene discussed is ABCB5; the disease is neoplasm.