Based on the publicly available Genome Aggregation Database and our previous study, we identified 5 CYP1A2 SNVs and 3 CYP2E1 SNVs associated with caffeine metabolism.18 There were no significant differences in the frequencies of any SNV among patients with PD, PSP, and MSA or HCs (Supplementary Table 9). This evidence concerns the gene CYP1A2 and multiple system atrophy.