Most recent studies with high fat diet-induced NAFLD rodent models and Larval Zebrafish model indicated that several signaling pathways, such as the nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE), sirtuin 3 (SIRT3)/AMPK/ACC, and AMPK-SREBP1c-SCD-1 pathways, are potential targets [39,41,49–51]. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.