To understand if the infection of CP and meninges prior to the infection of the cortex is unique to this strain of ZIKV and mouse, we employed another mouse model, the AG129 model (IFN-α/β/γ receptor knockout strain), and other ZIKV isolates (DAK AR 41524 and PRVABC59) representing African and American lineages in addition to PLCal_ZV[4,17]. The gene discussed is IFNA1; the disease is infection.