ACSL4 and hepatocellular carcinoma: Similarly, the works by Sun et al. [27] also revealed that high ACSL4 expression levels were significantly associated with Edmondson grade (p=0.010), AFP (p=0.001) and TNM stage (p=0.012), overall survival (p=0.001) and disease-free survival (DFS) (P=0.000) in HCC patients.