We found four strains with lower metabolic rate that might predict obesity susceptibility, Pax5+/- (Melka et al., 2012), Chst8-/- (Tachmazidou et al., 2017), Tfap2b+/- (Lindgren et al., 2009), and Pald1-/- (Cotsapas et al., 2009). The gene discussed is PALD1; the disease is obesity due to melanocortin 4 receptor deficiency.