Differential expression and dysfunction of EMC molecules, including collagens, have been widely reported in various cancers.25 Transcriptomic analyses have revealed that COL12A1 is involved in the development of CRC.16 In this study, we performed integrated bioinformatics analysis of public sequencing data to find the overexpression of COL12A1 in CRC. This evidence concerns the gene COL12A1 and cancer.