Especially for CSNK1A1L, belongs to the protein kinase superfamily, can phosphorylate a large number of proteins and participates in Wnt signaling which suggests that CSNK1A1L is associated with CRC.30 While TF SOX9 was widely reported to be involved in pathways like deactivation of the b‐catenin transactivating complex cAMP signaling pathway. The gene discussed is SOX9; the disease is colorectal carcinoma.