Integrating multiple biomarkers into a single signature, rather than performing individual biomarker analysis, is a promising approach that would improve clinical management.31 Based on the functional result of COL12A1 with its neighbored genes in CRC, we have identified that other five genes (COL1A2, COL3A1, COL5A1, COL5A2, and COL6A3) for ECM in correlation with COL12A1 belonged to FACITs families. The gene discussed is COL3A1; the disease is colorectal carcinoma.