Other studies found that abnormal increasing expression of COL12A1 was detected in ovary cancer (OC) and COL12A1 overexpression also induced drug resistance in OC cell lines.11, 12 Bioinformatics analysis has identified COL12A1 as an oncogenic driver in various cancers such as gastric, breast cancer, and pancreatic ductal adenocarcinoma (PCDA), and predicted a poor prognosis in survival.13, 14, 15 Recent studies have also revealed that the expression of COL12A1 is upregulated in CRC,16, 17 but the prognostic value and function of COL12A1 on CRC occurrence remain unclear. This evidence concerns the gene COL12A1 and breast cancer.