After coculture with lung cancer cells, the qPCR results revealed that a higher ERα in lung cancer cells could indeed increase the M2 polarization of macrophages, in both the THP‐1 cells collected from coculture with human NSCLC cells (Fig. 3A, upper left) and primary B6 Mφ collected from coculture with mouse LLC1 cells (Fig. 3A, lower left). This evidence concerns the gene ESR1 and lung carcinoma.