NFE2L2 and cancer: The glucose-induced glycation of NRF2 influences its protein-protein interaction properties and suppresses its oncogenic activity (Sanghvi et al., 2019), while the MGO-induced glycation of the tumor suppressor KEAP1 causes the accumulation of NRF2 in cells and thus promotes cancer progression (Fig. 3C) (Bollong et al., 2018).