However, when stratifying the effect of intrinsic subtype for tumour stage, we found that intrinsic subtype had no effect at all in patients in stage I, while Her2 (non-luminal) and basal-like tumours had worse prognosis than luminal-like tumours in patients with stage II and, especially, stages III and IV (Fig. 2b). The gene discussed is ERBB2; the disease is neoplasm.