This is the case of HUWE1, an E3 ubiquitin ligase required for the ubiquitination and subsequent degradation of different targets, such as the anti-apoptotic protein Mcl1 [myeloid cell leukemia sequence 1 (BCL2-related)], the tumor suppressor p53, core histones and DNA polymerase beta; mutations in the HUWE1 gene are associated with X-linked syndromic cognitive disability, where researchers found copy number variations [23], that perhaps could have similarities with some of the neurocognitive challenges seen in some individuals with Turner syndrome. The gene discussed is HUWE1; the disease is Turner syndrome.