BRCA1 and ovarian carcinoma: No cases of ovarian cancer had been found in the III generation female in this family, but genetic tests have shown that there were 1342A>C single mutations in the BRCA2 gene in III2, III4, and III7, and there were two mutations of BRCA1 (3326A>T) and BRCA2 (1342A>C) in III8.