A total of 8 mutations were found in the whole gene sequencing of BRCA1, including 3 nonsense mutations (2314C>T, 2543T>C, 4540T>C); two mutations have been recorded, which are associated with cervical cancer (2844C>T) [14] and endometriosis (3345A>G) [15], respectively; three new mutations (3780A>G, 5069A>G, 3326A>T) were found that no literature has been reported. The gene discussed is BRCA1; the disease is cervical cancer.