On the viSNE map, clear expression of multiple immunoregulatory proteins, including CTLA‐4, CD56, inducible T‐cell costimulator (ICOS), galectin‐9 (GAL9), CD86, ICOS ligand (ICOSL), OX40 and HLA‐DR, was observed in different MM cell clusters (Figure 1d). This evidence concerns the gene TNFRSF4 and Miyoshi myopathy.