On the viSNE map, clear expression of multiple immunoregulatory proteins, including CTLA‐4, CD56, inducible T‐cell costimulator (ICOS), galectin‐9 (GAL9), CD86, ICOS ligand (ICOSL), OX40 and HLA‐DR, was observed in different MM cell clusters (Figure 1d). The gene discussed is ICOS; the disease is Miyoshi myopathy.