Hence, to achieve a better understanding of the regulatory mechanism of the LINC00461/miR-144-3p/KPNA2 axis underlying cell invasion and migration in breast cancer, we divided cells into si-NC + oe-NC, si-LINC00461 + oe-NC and si-LINC00461 + oe-KPNA2 groups. The gene discussed is KPNA2; the disease is breast cancer.