Several studies have described that LINC00461 is a vital player in glioma progression responsible for mediating cell proliferation, invasion and migration via MAPK/ERK, PI3K/AKT and other possible signaling pathways [9], and it can be involved in the LINC00461/miR-149-5p/LRIG2 axis in turn participating in the progression of hepatocellular carcinoma [10]. This evidence concerns the gene MIR9-2HG and hepatocellular carcinoma.