APOE4 status has also been linked to Parkinson disease-related dementia [40], MS, tauopathy, vascular dementia (whose partial genetic overlap with AD may be explained by APOE genetic status) [41], mixed vascular dementia and AD [42], chronic traumatic brain injury [43], cerebral amyloid angiopathy [44], and cerebrovascular disease [45], as well as positive status of transactive response DNA-binding protein 43 (a protein previously linked to AD, frontotemporal dementia, and amyotrophic lateral sclerosis) [46]. Here, APOE is linked to amyotrophic lateral sclerosis.