In the APOE4 knock-in cells, we detected significantly decreased levels of expression of CCBE1 (a marker linked to lymphedema) and PDPN (adjusted p values ≤ 0.05, in both cases), and significantly increased levels of CD68 (a marker whose absence of detection during immunohistochemistry staining is linked to features of lymphatic vessels), as well as, PECAM1, compared with the APOE3 parental cells (adjusted p value ≤ 0.05, in both cases). This evidence concerns the gene APOE and lymphedema.