Our results from the blood glucose analysis validated well-established gene loci associated with type 2 diabetes with common SNPs in CDKAL1, SLC30A8, SND1-PAX4, IDE-KIF11-HHEX, CDKN2A-CDKN2B, KCNQ1 and CDC123,33,37,38 and identified a novel locus associated with FBG in DENND5B (Fig. 7a; Supplementary information, Table S10). Here, DENND5B is linked to type 2 diabetes mellitus.