PARP1 and cancer: Bourton et al.337 demonstrated that compared to normal BRCA cells, BRCA1+/− lymphoblastoid cells treated with olaparib, followed by IR exhibited decreased BRCA1 protein levels and increased apoptosis, resulting in radiation hypersensitivity; these results suggest that the combination of a PARP-1 inhibitor with radiotherapy has clinical relevance in treating BRCA1-associated cancers.