The most profound effect of Rab27a knockdown was observed in livers, where both CD11b+Ly6C+Ly6G+ granulocytic cells; CD11b+Ly6C+Ly6G- monocytic cells and CD11b+Ly6C-Ly6G- macrophage populations were significantly decreased upon knockdown of Rab27a in the primary tumor (Fig. 4B). This evidence concerns the gene ITGAM and neoplasm.