Furthermore, we identified multiple metalloproteases as well as growth factors associated with remodeling of extracellular matrix and EMT conversion such as MMP13, Wnt7a, PGF and FGF18 that were significantly upregulated in our dataset, providing further support for the perturbed tumor phenotype of shRab27a-KPC (Supplementary Table 4)30–38. Here, FGF18 is linked to neoplasm.