B2M and familial pancreatic carcinoma: To determine whether this was true for human pancreatic cancers, we examined RNAseq gene expression data from 35 human patients with resectable pancreatic adenocarcinoma (Table 1) and found that NLRC5 expression tightly correlated with expression of MHC-I heavy chain HLA molecules, light chain β2 microglobulin (B2M) and TAP1 expression (Fig. 5A).