CD8A and neoplasm: In order to determine if the generation of tumor-specific CD8+ T cells by tumor irradiation was sufficient to induce overcome αPD-L1 checkpoint blockade therapeutic resistance, we used the murine Panc02 model of pancreatic adenocarcinoma15 expressing a fusion of eGFP and the model antigen SIYRYYGL (SIY) and purified for high expression of antigen (Panc02SIY100)16.