Taken together, these results indicate that LmSIY-induced CD8+ T cells are cytotoxic, effectively traffic to SIY-expressing tumors and recognize antigen in the tumor; however, Panc02SIY100 cells are intrinsically resistant to killing by antigen-specific CD8+ T cells in the absence of phenotypic modifications induced here by IFNγ. Here, CD8A is linked to neoplasm.