BCL3 and colorectal carcinoma: Prompted by the results of previous studies in which Bcl-3 has a potential oncogenic role in CRC,17 as well as the research that Bcl-3 is necessary for pluripotency and self-renewal of mESCs,20,21 we hypothesized that Bcl-3 may play an important role in maintaining the homeostasis of colorectal CSCs.