First, Bcl-3 was found to promote CRC cell growth by stabilizing the c-Myc protein level and regulating ERK signaling.17 In addition, Bcl-3 promotes CRC tumorigenesis based on the activation of AKT signaling.18 Finally, Bcl-3 suppresses inflammation-associated colon tumorigenesis in epithelial cells by dampening tumorigenic NF-κB signaling.19 Moreover, previously uncovered evidence demonstrated the function of Bcl-3 in pluripotency maintenance. Here, AKT1 is linked to colorectal carcinoma.