B-cell lymphoma 3 (Bcl-3) is a member of the IκB family, and it is an important transcriptional regulator that forms complexes with p50 and p52 on DNA.12,13 Bcl-3 promotes breast cancer metastasis14 by stabilizing Smad3/TGFβ signaling.15 In glioblastoma cells, Bcl-3 significantly facilitated proliferation by stabilizing the expression of STAT3, p-STAT3, and STAT3 signaling target genes, including Bcl-2, MCL-1, and cyclin D1.16 Recently, the function of Bcl-3 in CRC has been reported by various research groups. Here, STAT3 is linked to colorectal carcinoma.