In the process of oligodendrocyte differentiation, HDAC-1 competes with β-catenin for TCF7L2 interaction to negatively regulate Wnt target gene expression.44 However, in breast and ovarian cancer, HDAC-1 and HDAC-7 are overexpressed in CSCs and are necessary to maintain CSCs. The gene discussed is TCF7L2; the disease is ovarian carcinoma.