In this regard it is important that mice with targeted mutations in either nrg1, nrg2, nrg3, or erbb4 exhibit a number of behavioral deficits that are relevant to traits affected in schizophrenia (Chen et al., 2010; Wen et al., 2010; Shamir et al., 2012; Lu et al., 2014; Hayes et al., 2016; Yan et al., 2018), and in two of the studies that tested the effects of antipsychotics in mutant mice, the behavioral deficits observed were improved (Tan et al., 2018; Yan et al., 2018). Here, NRG1 is linked to schizophrenia.