ERBB4 and Cognitive impairment: It is well documented that DA plays an important role in modulating cognitive functions in primates (Arnsten et al., 2015), and DA receptor-targeting drugs are known to ameliorate acute motor and cognitive deficits in rodents with disruptions in the NRG-ErbB4 pathway (Sotoyama et al., 2011; Andersson et al., 2012; Yan et al., 2018).