Nonetheless, there is some evidence that gut bacterial ClpB-like gene function, either by the same α-MSH-like epitope of ClpB E.coli with an effect on the anorexigenic pathway [18] or by others ClpB fragments with other unknown routes implicated, seems to have a role in the pathophysiology of obesity attributed to the gut microbiota. This evidence concerns the gene STAMBP and obesity disorder.