For example, patients with lung cancer carrying − 2578 C/C, − 1154 A/A and G/A, and 450 G/G genotypes have low VEGF expression, whereas high VEGF expression was detected in samples from patients carrying the − 2578 C/A, − 1154 G/G, and 450 G/C genotypes [13]. This evidence concerns the gene VEGFA and lung cancer.