MMP9 and neoplasm: In line with these results, co-culture of the monocytic cell line (THP-1) and BRCA2-mutated ovarian adenocarcinoma cell line (PEO-1) showed that the tumor-derived matrix metalloproteinase-stimulating factor (MMPSF) among with autocrine monocyte-derived TNFα stimulate the production of pro-MMP-9 [38].