TAM repolarization may be also induced by natural compounds, such as Onionin A, from onions and Deoxyschizandrin, from berries, that can abrogate pro-tumor activation of M2 macrophages and can reduce the production of the tumor-promoting factors (MMP9, CCL5, and VEGF) [48] (Figure 2A). This evidence concerns the gene CCL5 and neoplasm.