For example, Lee et al. [11] explored the therapeutic effects of human NSCs (hNSCs) obtained from fetal tissues transplanted bilaterally into the lateral ventricles of 13-month-old NSE/APP transgenic mice, an animal model of AD, with the amyloid precursor protein (APP) Swedish mutant allele controlled by the neuron-specific enolase (NSE) promoter. Here, APP is linked to Alzheimer disease.