LIMS1 and cancer: However, some of them might be important for the cell shape or cancer development, such as EPHB6 in tumor invasion and metastasis [47], LIMS1 (LIM zinc finger domain containing 1) in cell survival and differentiation [48], SIPA1L3 (signal-induced proliferation-associated 1-like protein 3) in cell polarity and cytoskeleton organization [49], or PPP2R4 (protein phosphatase 2 phosphatase activator) in cell growth and division [50].