AGT and cardiac hypertrophy: The amplitude of SOCE in adult cells was apparently lower in comparison to neonatal cardiomyocytes cells [23], but SOCE is re-activated in adult cardiomyocytes by mechanical and neurohumoral stress including AngII treatment; concordantly, cardiac expression of Orai1 and/or Stim1 is boosted in models of cardiac hypertrophy/remodeling, such as aortic banding [23], including transverse aortic constriction (TAC) in rats [24], TAC in mice [31,32], or related stress stimuli in neonatal rat ventricular cardiomyocytes [23,25].