An in vivo study [53] was carried out to assess the effect of H. coronarium aqueous extract to lower blood glucose level in induced-type 2 diabetes mellitus (T2DM) animal models (streptozotocin (STZ)-induced T2DM Wistar rats and C57BKSdb/db mice, a mice model with a mutation that results in chronic hyperglycemia, pancreatic beta cell atrophy, low insulin level and obesity). Here, INS is linked to type 2 diabetes mellitus.