ADAMTS15 and Familial prostate cancer: To consider the potential for both catalytic and non-catalytic functions for ADAMTS-15, early ‘androgen-responsive’ stage LNCaP and late ‘castrate-resistant’ stage PC-3 prostate cancer cell lines were generated that stably expressed wild-type ADAMTS-15 or the catalytically-inactive ADAMTS-15 (ADAMTS-15EA) and characterized in vitro and in vivo.