In humans, Darier disease (MIM #124200), also called Darier-White disease or keratosis follicularis, is inherited as an autosomal dominant trait and caused by heterozygous variants in the ATP2A2 gene encoding the endoplasmic/sarcoplasmic reticulum Ca2+-ATPase 2 (SERCA2) [7,8]. The gene discussed is ATP2A2; the disease is Darier disease.