KDM3A and colorectal carcinoma: The absence of KDM3A or KDM3B inhibits the Wnt target genes AXIN2 and DKK1. Moreover, both KDM3A and KDM3B directly interact and recruit β-catenin [26] in HCT116 CRC cells and specifically remove H3K9me2 from the Wnt target gene promoters, controlling the tumorigenic ability of human colorectal CSCs [26,34].