CD274 and cancer: The adipocytes’ activities in anti-PDL1 therapy most probably has three ways of action: (1) competitive inhibition for PDL1 between adipocytes and cancer cells, (2) direct contact with T-cells that by-passed cancer cell interaction with T cells and (3) PDL1 is localized intracytoplasmatically in a small population of adipocytes, thus being protected from anti-PDL1 antibody-based therapy [129].