Similar findings have been shown in cervical carcinoma (HeLa), where IMP significantly inhibited the tumor necrosis factor (TNF)-α-induced expression of cyclin D1 [32] and in HT-29 colon cancer cells affected by IMP treatment, resulting in cell cycle arrest in the G1 phase and apoptosis induction [33]. The gene discussed is CCND1; the disease is malignant colon neoplasm.