Moreover, identifying what leads to the context-dependent tumor suppressor or oncogenic effects of a single miRNA in different cancers will be critical not only to our basic knowledge of cancer progression, but also to enhance the clinical utility for that miRNA (for example, miR-141 targets ARHGAP7 (DLC1) to promote colorectal cancer cell growth, migration and invasion [306], but inhibits liver cancer progression by targeting TIAM1 [400]). This evidence concerns the gene TIAM1 and liver cancer.