Most studies reported that TAGL acts as a tumor suppressor [56], inhibiting cell migration, suppressing the 92-kDa type IV collagenase (MMP-9) [57], and being down-regulated by the Ras pathway [58] as well as silenced through epigenetic mechanisms, which involve TAGL promoter hypermethylation [59,60]. The gene discussed is PGLYRP2; the disease is neoplasm.