While two previous studies found IFN-λ1 or IFN-λ2 could inhibit or enhance HIV-1 infection of CD4+ T cells [72, 73], our findings support the IFN-λ3-mediated induction of an antiviral program in CD4+ T cells, with no indication of an enhancement of infection. This evidence concerns the gene IFNL3 and HIV-1 infection.