Further analysis that controlled for demographics and nadir CD4 levels showed that HIV duration (HR 0.90, 95% CI 0.81, 099, p = 0.038), hepatitis C (HR 4.60, 95% CI 1.40, 14.8, p = 0.012), and hypertension (HR 1.24, 95% CI 1.24, 11.9, p = 0.020) were significant factors of mortality (Table 4). The gene discussed is CD4; the disease is hypertensive disorder.