In a study of 40 HIV-infected adults with evidence of subclinical coronary atherosclerosis by coronary CT angiography, Lo et al. demonstrated that treatment with atorvastatin 40 mg daily for 12 months reduced non-calcified plaque volume and high-risk plaque features but did not significantly reduce hs-CRP or IL-6 [30]. Here, IL6 is linked to coronary atherosclerosis.