This prediction, based on in vivo results, might apply not only to GluN2B-C456Y-related cases of ASD [1,11–16] but also to various GRIN2B-related brain dysfunctions, including developmental delay, intellectual disability, attention-deficit/hyperactivity disorder, epilepsy, schizophrenia, obsessive-compulsive disorder, and encephalopathy [15,17]. The gene discussed is GRIN2B; the disease is Encephalopathy.