CD58 and candidiasis: For example, genetic susceptibility to candidiasis was investigated using genome-wide association studies (GWASs), which revealed a 19.4-fold increased risk in individuals with 2 or more single-nucleotide polymorphisms (SNPs) in LFA-3 (lymphocyte function-associated antigen 3), LCE4A (late cornified envelope 4A), and TAGAP (T cell activation RhoGTPase activating protein) loci [52].